| Title | Fecal High-Mobility Group Box 1 as a Marker of Early Stage of Necrotizing Enterocolitis in Preterm Neonates |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2021 |
| Authors | Vitali, Roberta, Terrin G., Palone Francesca, Laudadio I., Cucchiara S., Boscarino G., Di Chiara M., and Stronati L. |
| Journal | Frontiers in Pediatrics |
| Volume | 9 |
| Keywords | article, birth weight, case control study, clinical article, controlled study, densitometry, feces analysis, Female, high mobility group B1 protein, human, Italy, male, necrotizing enterocolitis, neonatal intensive care unit, newborn, prematurity, risk factor, Western blotting |
| Abstract | Introduction: An early diagnosis of necrotizing enterocolitis (NEC), a major gastrointestinal emergency in preterm newborns, is crucial to improve diagnostic approach and prognosis. We evaluated whether fecal high-mobility group box protein 1 (HMGB1) may early identify preterms at risk of developing NEC. Materials and Methods: A case-control study including neonates admitted at the Neonatal Intensive Care Unit (NICU) of the Sapienza University Hospital “Umberto I” in Rome, from July 2015 to December 2016. Stool samples obtained from cases (preterm newborns with NEC) and controls (newborns without NEC) were collected at the enrolment (T0) and within 7–14 days after the first sample collection (T1). HMGB1, extracted and measured with western blot, was reported as densitometry units (DUS). Results: HMGB1 levels in 30 cases (n = 28—Bell stage 1 |
| Notes | cited By 0 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108585278&doi=10.3389%2ffped.2021.672131&partnerID=40&md5=16daaab00487a2eaef9707c53690b4ce |
| DOI | 10.3389/fped.2021.672131 |
| Citation Key | Vitali2021 |
