| Title | Cytokine modulation in breast cancer patients undergoing radiotherapy: A revision of the most recent studies |
|---|---|
| Publication Type | Articolo su Rivista peer-reviewed |
| Year of Publication | 2019 |
| Authors | Marconi, R., Serafini A., Giovanetti Anna, Bartoleschi Cecilia, Pardini Maria Chiara, Bossi G., and Strigari L. |
| Journal | International Journal of Molecular Sciences |
| Volume | 20 |
| ISSN | 16616596 |
| Keywords | adult, anthracycline, autophagy, biological marker, Biomarkers, bisphosphonic acid derivative, brachytherapy, Breast cancer, Breast Neoplasms, breast radiotherapy, breast tumor, cancer growth, cancer hormone therapy, cancer immunotherapy, cancer staging, cancer stem cell, Cancer therapy, cognitive defect, colorectal cancer, Combined Modality Therapy, connective tissue growth factor, cytokeratin 19 fragment, cytokine, cytokine release, Cytokines, distant metastasis free survival, endoglin, enzyme linked immunosorbent assay, Epidermal Growth Factor, epidermal growth factor receptor 2, epithelial mesenchymal transition, erythema, external beam radiotherapy, fatigue, Female, gamma interferon, Gene expression, human, Humans, hypofractionated radiotherapy, immunology, Immunomodulation, immunosuppressive treatment, interleukin 10, interleukin 17, interleukin 1beta, interleukin 2, interleukin 6, interleukin 8, intraoperative radiotherapy, Ionizing radiation, melanoma, meta analysis, metabolism, monocyte chemotactic protein 1, Mortality, multimodality cancer therapy, osteoclast differentiation factor, overall survival, pancreas cancer, progression free survival, protein p53, radiation dose, radiation sickness, radiosensitivity, review, stereotactic body radiation therapy, systematic review, tamoxifen, transcription factor FOXP3, transforming growth factor, trastuzumab, treatment outcome, treatment response, tumor growth, tumor microenvironment, Tumor Necrosis Factor, tumor volume, upregulation, vasculotropin, wound fluid |
| Abstract | Breast cancer (BC) is the most common tumor and the second cause for cancer-related death in women worldwide, although combined treatments are well-established interventions. Several effects seem to be responsible for poor outcomes in advanced or triple-negative BC patients. Focusing on the interaction of ionizing radiation with tumor and normal tissues, the role of cytokine modulation as a surrogate of immunomodulation must still be explored. In this work, we carried out an overview of studies published in the last five years involving the cytokine profile in BC patients undergoing radiotherapy. The goal of this review was to evaluate the profile and modulation of major cytokines and interleukins as potential biomarkers of survival, treatment response, and toxicity in BC patient undergoing radiotherapy. Out of 47 retrieved papers selected using PubMed search, 15 fulfilled the inclusion criteria. Different studies reported that the modulation of specific cytokines was time-and treatment-dependent. Radiotherapy (RT) induces the modulation of inflammatory cytokines up to 6 months for most of the analyzed cytokines, which in some cases can persist up to several years post-treatment. The role of specific cytokines as prognostic and predictive of radiotherapy outcome is critically discussed. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
| Notes | cited By 0 |
| URL | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060133762&doi=10.3390%2fijms20020382&partnerID=40&md5=c623c62bef805dc06c1d66acc629fd82 |
| DOI | 10.3390/ijms20020382 |
| Citation Key | Marconi2019 |
