Epinephrine and norepinephrine plasma levels were assessed in dogs in relation to paw preference following an immune challenge with rabies vaccine. The results showed that both catecholamines increased after the vaccine administration, confirming the main role of the sympathetic nervous system in the modulation activity between the brain and the immune system. Moreover, ambidextrous dogs showed a significantly higher increase of epinephrine levels 8 days after immunization with respect to right- and left-pawed dogs, suggesting that the biological activity of this molecule could be key for a different immune response with regard to laterality. © 2010 Elsevier Ireland Ltd.

Cited By :13Export Date: 17 July 2015CODEN: NELEDCorrespondence Address: Siniscalchi, M.; Department of Animal Production, University of Bari, Strada Prov.le per Casamassima Km 3, 70010 Valenzano, Bari, Italy; email: m.siniscalchi@veterinaria.uniba.itChemicals/CAS: adrenalin, 51-43-4, 55-31-2, 6912-68-1; noradrenalin, 1407-84-7, 51-41-2; Epinephrine, 51-43-4; Norepinephrine, 51-41-2; Rabies VaccinesTradenames: rabisin, Merial, ItalyManufacturers: Merial, ItalyReferences: Banks, W.A., Neuroimmune networks and communication pathways: the importance of location (2004) Brain Behav. Immun., 18, pp. 120-122;Besedovsky, H.O., Sorkin, E., Felix, D., Haas, H., Hypothalamic changes during the immune response (1977) Eur. J. 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