Industrial symbiosis (IS) is a concept based on the idea of industrial ecosystems establishing symbiotic relationships between economically independent industries in order to make industry more sustainable and achieve collective benefits (the term "industrial" can also be extended to other anthropic systems). IS engages traditionally separate industries in a collective approach to competitive advantage involving physical exchange of materials, water, energy and by-products. Development of IS depends on an enabling context of social, informational, technological, economic and political factors. The Umbria region is characterized by a highly competitive productive and economic industrial system with a very significant presence of manufacturing activities. IS is in line with the recent European strategies for decoupling economic growth from natural resource consumption through the promotion of more sustainable business models. This paper reports the activities developed by Sviluppumbria (Multi-functional Agency of the Umbria Regional Authority) and ENEA (Italian Agency for New technologies, Energy and Sustainable Economic Development) in the framework of the Innetwork project 2016/2017 2014-2020 ROP Umbria ERDF , Axis 1, Action 1.2.1) to support SMEs to individuate symbiosis opportunities at regional level in 2017. The project for an Industrial Symbiosis (IS) network in Umbria had the following objectives: (I) analysis of the productive sector in Umbria (II) local network activation with public and private actors (III) collection and processing of data (IV) development of handbooks for two most significant synergies and involvement of the interested companies to focus on specific solutions for resources valorization; handbooks has been developed with the collaboration of involved companies. Two workshops have been held in Terni (07.04.2017) and Assisi (09.06.2017), where more than 50 SMEs participated, and about 200 resources in output and about 80 resources in input have been shared among companies. More than 200 potential synergies were found among the participating companies, some of them found by ENEA with a specific data analysis. The resource streams and synergies have been studied to realise two technical handbooks: one handbook for the production of nutraceutical substances and the other one for energy production both from scraps coming from agro-industry. In the present paper the handbook for the nutraceutical substances production from scraps coming from agro-industry will be presented.